Studies on Stability and Configurational Changes of Nickel and Copper Ethambutol Dihydrochloride and Metformin Hydrochloride in both Cationic and Anionic Surfactants

Present paper investigates and discusses formation and stability of two metal drug complexes under various external conditions and also results of kinetic investigation under changing pH as well as with various additives and solvent compositions in order to determine its configurational alterations. These studies are important from the view point of application of the metal-drug complexes under changing human abdominal environment. Two drugs namely Ethambutol dihydrochloride and Metformin hydrochloride used for tuberculosis and diabetic treatment , the most prevalent diseases in tropical countries, have been chosen for present studies.